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Drug Interactions
When you are taking Prozac, it is especially important that your health care professional know if you are taking any of the following:
- Selective serotonin reuptake inhibitors, other (cital
opram [Celexa], fluvoxamine [e.g., Luvox], paroxetine [e.g., Paxil], sertraline [e.g., Zoloft]) or
- Street drugs (LSD, MDMA [e.g., ecstasy], marijuana) or
- Sumatriptan (e.g., Imitrex) or <
br> - Tramadol (e.g., Ultram) or
- Trazodone (e.g., Desyrel) or
- Tryptophan or
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Warning
Seizures:
Fluoxetine should be used with caution in patients with a history of convulsive disorders. The incidence of seizures associated with fluoxetine during clinical trials did not appear to d
iffer from that reported with other marketed antidepressants; however, patients with a history of convulsive disorders were excluded from these trials.
Concurrent administration with electro
shock therapy should be avoided because of the absence of experience in this area. There have been rare reports of a prolonged seizure in patients on fluoxetine receiving ECT treatment.
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Proper Use of This Medicine
Prozac comes as a capsule, tablet, and liquid to take by mouth. It is usually taken once or twice a day and may be taken with or without food. Follow the directions on your prescription label carefull
y, and ask your doctor or pharmacist to explain any part you do not understand. Take Prozac exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Prozac oral liquid comes with a specially marked dropper for measuring the dose. Ask your pharmacist to show you how to use the dropper. Dilute the liquid in 4 ounces (120 ml) of water, apple j
uice, or Gatorade just before taking it.
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Significant Interactions:
P450 isozyme (IID6): - Like other selective serotonin reuptake inhibitors, fluoxetine inhibits the specific hepatic cytochrome P450 isozyme (IID6) which is responsible for the metabolism of debrisoqui
ne and sparteine. Although the clinical significance of this effect has not been established, inhibition of IID6 may lead to elevated plasma levels of co-administered drugs which are metabolized by th
is isozyme. Drugs metabolized by cytochrome P450IID6 include the tricyclic antidepressants (e.g., nortriptyline, amitriptyline, imipramine, and desipramine), phenothiazine neuroleptics (e.g., perphena
zine and thioridazine), and Type 1C antiarrhythmics (e.g., propafenone and flecainide).
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Overdose
- unsteadiness
- confusion
- unresponsiveness
- nervousness
- tremor
- dizziness
- rapid, irregular, or pounding heartbeat
- seeing things or hearing voices tha
t do not exist (hallucinating)
- fever
- fainting
- coma
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What special precautions should I follow?
Pregnancy¡XOne study of babies whose mothers had taken Prozac while they were pregnant found some problems in the babies, such as premature birth, jitteriness, and trouble in breathing or nursing. How
ver, four other studies did not find any problems in babies or young children whose mothers had taken Prozac while they were pregnant. Tell your doctor if you are pregnant or if you may become pregnan
t while you are taking this medicine.
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