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Side Effects
Check with your doctor immediately if any of the following side effects occur, especially if several of them occur together:

Bleeding or crusting sores on lips; chest pain; fever with or wi thout chills; hive-like swellings (large) on eyelids, face, lips, and/or tongue ; muscle cramps or pain; red, thickened, or scaly skin; shortness of breath, troubled breathing, tightness in chest, or wheezing; skin rash, itching, or hives; sores, ulcers, or white spots in mouth (painful); sore throat

How should this medicine be used?
This medicine will relieve a headache best if you take it as soon as the headache begins. If you get warning signs of a migraine, take this medicine as soon as you are sure that the migraine is coming . This may even stop the headache pain from occurring. Lying down in a quiet, dark room for a while after taking the medicine also helps to relieve headaches.

Symptoms of overdose
Seek emergency medical attention. Symptoms of an acetamino phenbutalbita lcaffeine - Esgic overdose include insomnia, restlessness, tremor, nausea, vomiting, diarrhea, abdominal pain, sweating, seizur es, drowsiness, decreased breathing,

Description
Esgic contains Acetaminophen / butalbital / caffeine. Acetaminophen is a pain reliever and fever reducer. Butalbital is in a class of drugs called barbiturates that slow down your central nervous syst em (brain and nerve impulses) causing relaxation. Caffeine is believed to constrict dilated blood vessels that may contribute to tension headaches. Together, acetaminophen, butalbital, and caffeine ar e used to relieve complex tension (muscle contraction) headaches although precisely how it works is unknown.

Possible food and drug interactions when taking this medication
It is especially important that your health care professional know if you are taking any of the following:

- Antidepressants, tricyclic (amitriptyline [e.g., Elavil], amoxapine [e.g., Asendi n], clomipramine [e.g., Anafranil], desipramine [e.g., Pertofrane], doxepin [e.g., Sinequan], imipramine [e.g., Tofranil], nortriptyline [e.g., Aventyl], protriptyline [e.g., Vivactil], trimipramine [ e.g., Surmontil]) or
- Central nervous system (CNS) depressants (medicines that often cause drowsiness)ˇXThese medicines may add to the effects of butalbital and increase the chance of drowsiness or other side effects
- Divalproex (e.g., Depakote) or
- Valproic acid (e.g., Depakene)ˇXThe chance of side effects may be increased

Precautions while Using this Medicine
Before you have any medical tests, tell the person in charge that you are taking this medicine. Caffeine (present in some butalbital and acetaminophen combinations) interferes with the results of cert ain tests that use dipyridamole (e.g., Persantine) to help show how well blood is flowing to your heart. Caffeine should not be taken for 8 to 12 hours before the test. The results of other tests may also be affected by butalbital and acetaminophen combinations.




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