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DRUG ABUSE AND DEPENDENCE :
Although preliminary animal and human investigations suggest that buspirone may be significantly devoid of potential for producing physical or psychological dependence, only extensive clinical experie
nce with the drug will provide conclusive evidence. Meanwhile, physicians should carefully evaluate patients for a history of drug abuse and follow such patients closely, observing them for signs of b
uspirone misuse and abuse.
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What side effects may occur?
Although side effects from buspirone are not common, they can occur. Tell your doctor if any of these symptoms are severe or do not go away:
- drowsiness
- upset stomach
- vomiting
- constipation
- diarrhea
- stomach pain
- headache
- dry mouth
- depression
- excitement
- fatigue
- nervousness
- difficulty sleeping
- lighth
eadedness
- weakness
- numbness
If you experience any of the following symptoms, call your doctor immediately:
- skin rash
- itching
- fast or irregular heartbe
at
- blurred vision
- unusual movements or the head or neck muscles
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Why is this medication prescribed?
Short-term symptomatic relief of excessive anxiety in patients with generalized anxiety disorder (psychoneurotic disorder).
Eight 3-way short-term, controlled clinical trials involving buspi
rone, diazepam and placebo are considered central to the evaluation of buspirone as an anxiolytic agent. In 4 of the 8 clinical trials, buspirone demonstrated a significant difference from placebo. In
the other 4 trials, there was no significant difference between buspirone and placebo, but a significantly greater improvement was observed in 2 of these trials with diazepam than with placebo. The a
dverse effect profiles of buspirone and diazepam in these clinical trials were, however, different.
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Other medical problems
Geriatrics:
Buspirone has not been systematically evaluated in older patients. Although it would appear from limited pharmacokinetic and clinical studies that buspirone does not behave differently
in the elderly, there is little known about the effects of buspirone in this age group at doses above 30 mg/day. Therefore, it is recommended that buspirone should be used in the elderly at doses not
exceeding 30 mg/day for a duration not exceeding 4 weeks.
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Drug Interactions
Because the effects of concomitant administration of buspirone with most other psychotropic drugs have not been studied, the concomitant use of buspirone with other CNS active drugs should be approach
ed with caution.
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How to Use
Buspirone comes as a tablet to take by mouth. It usually is taken two or three times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any
part you do not understand. Take buspirone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Continue to take buspirone even if you fe
el well. Do not stop taking buspirone without talking to your doctor, especially if you have taken large doses for a long time. Your doctor probably will decrease your dose gradually. This drug must b
e taken regularly for a few weeks before its full effect is felt.
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